Inter and Napoli go head-to-head for second place and the chance to chase down leaders Milan, with Romelu Lukaku and Lautaro Martinez against Dries Mertens and Lorenzo Insigne.
It kicks off at San Siro at 19.45 GMT, you can follow the build-up and action as it happens from all SEVEN of today’s Serie A games on the LIVEBLOG.
Only one point separates these teams in the table, although that is the one that was docked from Napoli due to the abandoned Juventus game, a matter that is still subject to appeal.
Inter are out of Europe and must put all their eggs in the Serie A basket, but Arturo Vidal, Alexis Sanchez, Radja Nainggolan and Matias Vecino are injured.
Achraf Hakimi is not at 100 per cent either, so Matteo Darmian and Ashley Young start on the wings, supporting Lukaku and Lautaro Martinez.
Napoli are going to be without Victor Osimhen until 2021 after he dislocated his shoulder on international duty with Nigeria last month.
Mertens therefore takes the centre-forward role, with Chucky Lozano, Piotr Zielinski and Lorenzo Insigne fanning out behind him.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Gagliardini, Young; R Lukaku, Lautaro Martinez
Napoli: Ospina; Di Lorenzo, Manolas, Koulibaly, Mario Rui; Bakayoko, Demme; Lozano, Zielinski, L Insigne; Mertens