Cristiano Ronaldo, Ivan Perisic, Hakan Calhanoglu and Milan Skriniar were the Serie A players to score while on international duty in the World Cup qualifiers.
Portugal had been astonishingly losing to Luxembourg, who had just earned a 1-0 win against the Republic of Ireland last week.
However, Diogo Jota equalised and Cristiano Ronaldo completed the turnaround with a cushioned volley, completing the give-and-go with Joao Cancelo.
That was CR7’s 103rd goal at international level, only six shy of the all-time record set by Ali Daei, and it means he has found the net for Portugal in every calendar year since 2004.
Joao Palhinha added a third late on for the final 3-1 result.
Calhanoglu was decisive again for very impressive Turkey, who have had an impressive start to the 2022 World Cup qualifiers.
The Milan midfielder first provided an assist for Kenan Karaman, then scored with a stunning volley from outside the box, but it all fell apart and Latvia grabbed a 3-3 draw.
Sassuolo defender Mert Muldur also started and won a penalty.
There were some surprising results, as Josip Ilicic and Jasmin Kurtic started when Slovenia suffered a shock 1-0 defeat to Cyprus.
Inter’s Ivan Perisic came off the bench to break the deadlock for Croatia, 62 minutes into their trip to Malta, then added an assist for Josip Brekalo in the 3-0 win.
His club teammate Milan Skriniar was also on target in Slovakia’s 2-1 victory over Russia with a trademark header.
Belgium rotated their squad against Belarus, leaving Romelu Lukaku, Dries Mertens and Alexis Saelemaekers on the bench, but still won 8-0.