Federico Chiesa, Alvaro Morata and Cristiano Ronaldo are expected to start for Juventus against Inter’s Romelu Lukaku, Lautaro Martinez and Arturo Vidal.
It kicks off on Sunday at 19.45 GMT, click here for a match preview.
The Nerazzurri have almost a full squad to choose from, save for Danilo D’Ambrosio, Andrea Pinamonti and Matias Vecino.
Matteo Darmian is available again, but probably only from the bench, as Achraf Hakimi and Ashley Young take the wings.
Lukaku and Lautaro will be the front pairing, with Vidal preferred to Roberto Gagliardini in the usual midfield with Nicolò Barella and Marcelo Brozovic.
Juventus are still missing Matthijs de Ligt, Alex Sandro and Juan Cuadrado due to COVID-19, with Paulo Dybala injured for at least another two weeks with a knee ligament problem.
A choice needs to be made in defence between Giorgio Chiellini and Merih Demiral, while Weston McKennie probably won’t be risked from the start, giving Adrien Rabiot the nod.
Chiesa and Ramsey have shaken off knocks and should be in the starting XI with Rodrigo Bentancur and Gianluca Frabotta.
There are no other alternatives upfront, it’s got to be Morata and Ronaldo, sending Dejan Kulusevski to the bench after his impressive display in the Coppa Italia against Genoa midweek.
Inter (3-5-2): Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Brozovic, Vidal, Young; Lautaro Martinez, R Lukaku
Juventus (4-4-2): Szczesny; Danilo, Bonucci, Chiellini, Frabotta; Chiesa, Bentancur, Rabiot, Ramsey; Morata, Ronaldo